Director/PDMR Shareholding


Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 1 August 2016, the interest of Marc Dunoyer, a person discharging managerial
responsibilities, in the ordinary shares of AstraZeneca PLC changed as detailed
below.

The change in interest relates to the vesting of awards of shares made in August
2013 under the AstraZeneca Performance Share Plan and the AstraZeneca Restricted
Share Plan.

Following the application of performance measures specified at the time of
grant, Mr Dunoyer has become beneficially entitled to 78% of the shares
originally awarded. In accordance with the plan rules, any unvested part of the
award has immediately and irrevocably lapsed.

After sufficient vested shares were withheld to satisfy certain tax obligations
arising on the vesting, Mr Dunoyer has become beneficially entitled to and has
received 43,730 shares into a personal brokerage account.

For tax purposes, the fair market value of the shares at vest was 5048 pence per
share being the closing price of AstraZeneca ordinary shares on the last trading
day preceding the vesting day.

The attached notification, made in accordance with the requirements of the EU
Market Abuse Regulation, gives further detail.

Notification and public disclosure of transactions by persons discharging
managerial responsibilities and persons closely associated with them

1      Details of the person discharging
       managerial responsibilities / person
       closely associated
a)     Name                                 Marc Dunoyer
2      Reason for the notification
a)     Position/status                      Chief
                                            Financial
                                            Officer
b)     Initial notification /Amendment      Initial
                                            notification
3      Details of the issuer, emission
       allowance market participant, auction
       platform, auctioneer or auction monitor
a)     Name                                 AstraZeneca
                                            PLC
b)     LEI                                  Not
                                            applicable
4      Details of the transaction(s): section
       to be repeated for (i) each type of
       instrument; (ii) each type of
       transaction; (iii) each date; and (iv)
       each place where transactions have been
       conducted
a)     Description of the financial         Ordinary
       instrument, type of instrument       Shares of
       Identification code                  US$0.25 each
                                            in
                                            AstraZeneca
                                            PLC
                                            GB0009895292
b)     Nature of the transaction            Acquisition
                                            of Ordinary
                                            Shares
                                            pursuant to
                                            a vesting of
                                            awards under
                                            the
                                            AstraZeneca
                                            Performance
                                            Share Plan
                                            and the
                                            AstraZeneca
                                            Restricted
                                            Share Plan
c)     Price(s) and volume(s)                Price(s)  Volume(s)
5048   43,730
pence
d)     Aggregated information - Aggregated  Not
       volume - Price                       applicable -
                                            single
                                            transaction
e)     Date of the transaction              1 August
                                            2016
f)     Place of the transaction             London

A C N Kemp

Company Secretary

1 August 2016